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2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride

2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride

CAS: 858474-14-3

Molecular Formula: C22H24N2O2

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2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride - Names and Identifiers

Name 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
Synonyms NSC23925
NSC-23925
NSC23925 HCl
2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
4-Quinolinemethanol, 2-(4-methoxyphenyl)-α-2-piperidinyl-, hydrochloride
[2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride
(2-(4-Methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol dihydrochloride
CAS 858474-14-3

2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride - Physico-chemical Properties

Molecular FormulaC22H24N2O2
Molar Mass348.43816
Solubility H2O: soluble5mg/mL (clear solution)
Appearancepowder
Colorwhite to beige
Storage Conditionroom temp
In vitro study NSC23925 is a novel, selective and effective P-glycoprotein (Pgp) inhibitor. SKOV-3 cells with long-term exposure of 1 μM NSC23925 show stable growth in culture medium. NSC23925 specifically inhibits Pgp overexpression to prevent the emergence of paclitaxel resistance during paclitaxel treatment. NSC23925 reverses chemoresistance in a wide variety of tumor types where Multidrug resistance 1 (MDR1) is highly expressed. Maximal reversal of MDR is typically seen in NSC23925 doses between 0.5 and 1 µM. The IC 50 for NSC23925 is 8 µM in SKOV-3/SKOV-3 TR and 25 µM in OVCAR8/OVCAR8 TR cell lines, whereas the mean concentration of NSC23925 required for maximal reversal of resistance in SKOV-3 TR or OVCAR8 TR to cytotoxic drugs is 0.5 µM to 1 µM.
In vivo study Both saline alone and NSC23925 alone treated tumors grow progressively. The usage of NSC23925 in paclitaxel chemotherapy significantly prolongs anticancer efficacy of paclitaxel.

2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride - Risk and Safety

Hazard SymbolsT - Toxic
Toxic
Risk Codes25 - Toxic if swallowed
Safety Description45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDsUN 2811 6.1 / PGIII
WGK Germany3

2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride - Preparation solution concentration reference

 1mg5mg10mg
1 mM2.87 ml14.35 ml28.699 ml
5 mM0.574 ml2.87 ml5.74 ml
10 mM0.287 ml1.435 ml2.87 ml
5 mM0.057 ml0.287 ml0.574 ml
Last Update：2024-01-02 23:10:35

2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride - Reference Information

biological activity NSC23925 is a novel, selective and potent P-glycoprotein (Pgp) inhibitor.
Target P-glycoprotein
Last Update：2024-04-10 22:29:15
2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride Visit Supplier Webpage Request for quotation
CAS: 858474-14-3
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride Visit Supplier Webpage Request for quotation
CAS: 858474-14-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
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